CURRICULUM VITAE
Shinobu Sakurada, Ph.D.
Chairman and Professor
Department of Physiology and Anatomy
Tohoku Pharmaceutical University
4-4-1 Komatsushima, Aoba-ku
Sendai 981-8558, Japan
Phone: +81-22-727-0124
Fax: +81-22-727-0125
Education
1969 B.S. (Pharmacy) Tohoku Pharmaceutical University, Sendai, Japan
1971 M.S. (Pharmacology) Tohoku Pharmaceutical University, Sendai, Japan
1978 Ph.D. (Pharmacology) Tohoku Pharmaceutical University, Sendai, Japan
Academic appointments
1971-1977 Instructor, Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
1971-1973 Visiting Researcher, Brain Disease Institute, Tohoku University School of Medicine, Sendai, Japan
1978-1986 Assistant Professor, Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
1981-1981 Postdoctoral Fellowship, Department of Pharmacology (Prof. L. Terenius’s Lab.), Uppsala University, Uppsala, Sweden
1985-1986 Postdoctoral Fellowship, Department of Pharmacology (Prof. G. Nistico’s Lab.), University of Catanzaro, Roccelletta di Borgia, Italy
1987-1995 Associate Professor, Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
1996-present Chairman and Professor, Department of Physiology and Anatomy, Tohoku Pharmaceutical University, Sendai, Japan
Administrative Responsibilities
1988-present Member of the board of the Japanese Pharmacological Society
1996-present Chairman at the Department of Physiology and Anatomy, Tohoku Pharmaceutical University
1997-2004 President of the Animal Resource Center, Tohoku Pharmaceutical University
1998-present Member of the board of the Japanese Society of Neuropsychopharmacology
1999 President of the Japanese Narcotics Research Conference
2001-2004 Vice Director of the Department of Student Affair, Tohoku Pharmaceutical University
2002 Reviewing Editor of the dissertation, National University of Singapore
2002-2003 Member of the Research Council Coordinating Committee for the Grant-in-Aid for Scientific Research in the Japan Society for the Promotion of Science
2002-present Member of the Executive Committee of the Japanese Society of Pharmacy
2004 President of “International symposium for opioid and pain-related peptide in Sendai”
2004-2007 Director of the Department of Student Affair, Tohoku Pharmaceutical University
2004-present Member of the Executive Committee of Tohoku Pharmaceutical University
2004-2008 President of the Japan Branch of the International Neuropeptide Society
2005-2010 Director of the High Technology Research Center, Tohoku Pharmaceutical University
2006-2007 Vice Director of the Tohoku Branch of the Japanese Society of Pharmacy
2006-present Board of the directors of the Japanese Society for Pharmaceutical Palliative Care and Sciences
2007-2008 Director of the Tohoku Branch of the Japanese Society of Pharmacy
2007-present Board of the directors of Tohoku Pharmaceutical University
2007-present Director of the Department of Academic Affair, Tohoku Pharmaceutical University
2008 President of “XI WORKSHOP ON APOPTOSIS IN BIOLOGY AND MEDICINE”
2009 President of Japan Histamine Research Society
Professional Societies
Japanese Pharmacological Society
Japanese Society of Neuropsychopharmacology
Japanese Society of Pharmacy
Physiological Society of Japan
Japanese Narcotics Research Conference
Japanese Society for Pharmaceutical Palliative Care and Sciences
International Narcotics Research Conference (INRC)
International Association for the study of Pain (IASP)
Research Activities
1 Characterization of physiological role of newly identified splicing variants of -opioid receptors.
2 Development of new -opioid peptides as an analgesic.
3 Characterization of the physiological role of neurotransmitters for spinal pain transmission.
4 Characterization of the mechanism of neuropathic pain (nerve injured neuropathy, inflammatory chronic pain, cancer pain, multiple sclerosis).
Current research group consists of 33 persons, including 4 faculty, 1 postdoctoral fellow, 9 graduate students, 14 undergraduate students.
Publication List
1. H. Nakahama, M. Yamamoto, S. Sakurada, K. Shima: Effects of cytidine diphosphate choline on the nervous system in cats. Exp. Neurol. 45: 220-227, 1974.
2. Y. Kimura, N. Kisaki, S. Sakurada, T. Tadano: On the brain monoaminergic systems relating to ejaculation. I. Brain dopamine and ejaculation. Andrologia 8: 313-320, 1976.
3. Y. Kimura, N. Kisaki, S. Sakurada, T. Tadano: On the brain monoaminergic systems relating to ejaculation. II. Brain serotonin and ejaculation. Andrologia 9: 50-54, 1977.
4. S. Orikasa, S. Sakurada, K. Kisara: Head-twitch response induced by tyramine. Psychopharmacology 67: 53-59, 1980.
5. T. Miyagawa, S. Sakurada, K. Shima, R. Ando, N. Takahashi, K. Kisara: Effects of morphine on evoked potentials recorded from the amygdala by tooth pulp stimulation in cats. Jpn. J. Pharmacol. 30: 463-469, 1980.
6. R. Andoh, K. Shima, T. Miyagawa, S. Sakurada, K. Kisara, K. Ohsawa, M. Takahashi: Excitatory effects of dihydrocapsaicin on nociceptive neurons in the medial thalamus. Jpn. J. Pharmacol. 30: 599-605, 1980.
7. H. Nakahama, K. Shima, K. Aya, K. Kisara, S. Sakurada: Antinociceptive action of morphine and pentazocine on unit activity in the nucleus centralis lateralis, nucleus ventralis lateralis and nearby structures of the cat. Pain 10: 47-56, 1981.
8. Y. Sasaki, Y. Akutsu, K. Suzuki, S. Sakurada, K. Kisara: Structure and analgesic activity relationship of cyclo-tyrosyl-arginyl and its three stereoisomers. Chem. Pharm. Bull. 29: 3403-3406, 1981.
9. R. Andoh, S. Sakurada, T. Sato, N. Takahashi, K. Kisara: Potentiating effects of prostaglandin E2 on bradykinin and capsaicin responses in medial thalamic nociceptive neurons. Jpn. J. Pharmacol. 32: 81-89, 1982.
10. T. Miyagawa, S. Sakurada, K. Kisara, T. Sato, R. Andoh, N. Takahashi, T. Sakurada, K. Shima: Effects of morphine on single unit activity of the amygdala in cats. Jpn. J. Pharmacol. 32: 867-873, 1982.
11. S. Sakurada, T. Sakurada, H. Jin, T. Sato, K. Kisara, Y. Sasaki, K. Suzuki: Antinociceptive activities of synthetic dipeptides in mice. J. Pharm. Pharmacol. 34: 750-751, 1982.
12. Y. Sasaki, Y. Akutsu, M. Matsui, K. Suzuki, S. Sakurada, T. Sato, K. Kisara: Studies on analgesic oligopeptides. II. Structure-activity relationship among thirty analogs of a cyclic dipeptide, cyclo(-Tyr-Arg-). Chem. Pharm. Bull. 30: 4435-4443, 1982.
13. S. Kawamura, S. Sakurada, T. Sakurada, K. Kisara, Y. Akutsu, Y. Sasaki, K. Suzuki: Antinociceptive effect of centrally administered cyclo (N-methyl-L-Tyr-L-Arg) in the rat. Eur. J. Pharmacol. 93: 1-8, 1983.
14. T. Sakurada, S. Sakurada, S. Watanabe, H. Matsumura, K. Kisara, Y. Akutsu, Y. Sasaki, K. Suzuki: Actions of intracerebroventricular administration of kyotorphin and an analog on thermoregulation in the mouse. Peptides 4: 859-863, 1983.
15. Y. Sasaki, M. Matsui, M. Taguchi, K. Suzuki, S. Sakurada, T. Sato, T. Sakurada, K. Kisara: D-Arg2-dermorphin tetrapeptide analogs: a potent and long-lasting analgesic activity after subcutaneous administration. Biochem. Biophys. Res. Commun. 120: 214-218, 1984.
16. T. Sato, S. Sakurada, T. Sakurada, S. Furuta, N. Nakata, K. Kisara, Y. Sasaki, K. Suzuki: Comparison of the antinociceptive effect between D-Arg containing dipeptides and tetrapeptides in mice. Neuropeptides 4: 269-279, 1984.
17. A. Hara, T. Sakurada, S. Sakurada, H. Matsumura, K. Kisara: Antinociceptive effects of neonatal capsaicin in rats with adjuvant arthritis. Naunyn-Schmiedeberg’s Arch. Pharmacol. 326: 248-253, 1984.
18. S. Furuta, K. Kisara, S. Sakurada, T. Sakurada, Y. Sasaki, K. Suzuki: Structure-antinociceptive activity studies with neurotensin. Br. J. Pharmacol. 83: 43-48, 1984.
19. T. Sakurada, S. Sakurada, S. Watanabe, S. Kawamura, T. Sato, K. Kisara, Y. Akutsu, Y. Sasaki, K. Suzuki: Comparison of the antinociceptive effects of intracerebroventricular injection of kyotorphin, cyclo (N-methyl-Tyr-Arg) and Met-enkephalin in mice. Neuropharmacology 23: 7-12, 1984.
20. S. Kawamura, S. Sakurada, T. Sakurada, K. Kisara, Y. Akutsu, Y. Sasaki, K. Suzuki: Potentiation of cyclo (N-methyl-Tyr-Arg)-induced antinociceptive activity by thyrotropin-releasing hormone in mice. J. Pharm. Pharmacol. 36: 142-144, 1984.
21. T. Sato, S. Sakurada, T. Sakurada, K. Kisara, Y. Sasaki, Y. Akutsu, K. Suzuki: Comparison of the antinociceptive effect between the cyclic dipeptide cyclo[Tyr(Et)-homoarginine] and the linear dipeptide Boc-Tyr(Et)- homoarginine-OMe in rats. Jpn. J. Pharmacol. 34: 1-8, 1984.
22. Y. Sasaki, M. Matsui, H. Fujita, M. Hosono, M. Taguchi, K. Suzuki, S. Sakurada, T. Sato, T. Sakurada, K. Kisara: Studies on analgesic oligopeptides. III. Synthesis and analgesic activity after subcutaneous administration of [D-Arg2]dermorphin and its N-terminal tetrapeptide analogs. Chem. Pharm. Bull. 33: 1528-1536, 1985.
23. Y. Sasaki, M. Matsui, H. Fujita, M. Hosono, M. Taguchi, K. Suzuki, S. Sakurada, T. Sato, T. Sakurada, K. Kisara: The analgesic activity of D-Arg2-dermorphin and its N-terminal tetrapeptide analogs after subcutaneous administration in mice. Neuropeptides 5: 391-394, 1985.
24. H. Matsumura, T. Sakurada, A. Hara, S. Sakurada, K. Kisara: Characterization of the hyperalgesic effect induced by intrathecal injection of substance P. Neuropharmacology 24: 421-426, 1985.
25. T. Sato, S. Sakurada, T. Sakurada, K. Kisara, Y. Sasaki, K. Suzuki: A comparison of the antinociceptive and behavioral effects of D-Arg substituted dipeptides and tetrapeptides in mice. Peptides 6: 35-40, 1985.
26. K. Suzuki, H. Fujita, M. Matsui, Y. Sasaki, S. Sakurada, T. Sakurada, K. Kisara: Studies on analgesic oligopeptides. IV. Synthesis and analgesic activity of N-terminal shorter analogs of [D-Arg2]dermorphin and des-Tyr1-dermorphin analogs. Chem. Pharm. Bull. 33: 4865-4869, 1985.
27. S. Kawamura, S. Sakurada, T. Sakurada, K. Kisara, Y. Sasaki, K. Suzuki: The antinociceptive effects of histidyl-proline diketopiperazine and thyrotropin-releasing hormone in the mouse. Eur. J. Pharmacol. 112: 287-294, 1985.
28. H. Matsumura, T. Sakurada, A. Hara, H. Kuwahara, R. Ando, S. Sakurada, K. Kisara: Intrathecal substance P analogue causes motor dysfunction in the rat. Neuropharmacology 24: 811-813, 1985.
29. Y. Sasaki, M. Hosono, M. Matsui, H. Fujita, K. Suzuki, S. Sakurada, T. Sakurada, K. Kisara: On the degradation of dermorphin and D-Arg2-dermorphin analogs by a soluble rat brain extract. Biochem. Biophys. Res. Commun. 130: 964-970, 1985.
30. T. Kosaka, S. Sakurada, T. Sakurada, T. Sato, K. Kisara, M. Hosono, Y. Sasaki, K. Suzuki: Antinociceptive properties of a new tetrapeptide, Asn-Ala-Gly-Ala, in mice. Arch. Int. Pharmacodyn. Ther. 277: 280-288, 1985.
31. K. Kisara, S. Sakurada, T. Sakurada, Y. Sasaki, T. Sato, K. Suzuki, H. Watanabe: Dermorphin analogues containing D-kyotorphin: structure-antinociceptive relationships in mice. Br. J. Pharmacol. 87: 183-189, 1986.
32. N. Nakata, S. Sakurada, T. Sakurada, K. Kisara, Y. Sasaki, K. Suzuki: Physical dependence of a dermorphin tetrapeptide analog, [D-Arg2,Sar4]-dermorphin (1-4) in the rat. Pharmacol. Biochem. Behav. 24: 27-31, 1986.
33. S. Sakurada, H. Watanabe, T. Sakurada, R. Andoh, K. Kisara, Y. Sasaki, K. Suzuki: Potentiation of dermorphin-induced antinociception by peptidase inhibitors. J. Pharm. Pharmacol. 38: 230-232, 1986.
34. T. Fujii, Y. Ohbuchi, S. Takahashi, T. Sakurada, S. Sakurada, R. Ando, K. Kisara: Studies on the hypothermic response of capsaicin and its analogue in mice. Arch. Int. Pharmacodyn. Ther. 280: 165-176, 1986.
35. G. Bagetta, S. Sakurada, M.T. Corasaniti, F. Froio, G. Nistico: Behavioural and electrocortical changes induced by muscimol in rats withdrawn from chronic treatment with diazepam. Neuropharmacology 26: 725-730, 1987.
36. G. Bagetta, M.T. Corasaniti, M.C. Strongoli, S. Sakurada, G. Nistico: Behavioural and ECoG spectrum power effects after intraventricular injection of drugs altering dopaminergic transmission in rats. Neuropharmacology 26: 1047-1052, 1987.
37. K. Takahashi, T. Sakurada, S. Sakurada, H. Kuwahara, A. Yonezawa, R. Ando, K. Kisara: Behavioural characterization of substance P-induced nociceptive response in mice. Neuropharmacology 26: 1289-1293, 1987.
38. T. Sato, S. Sakurada, T. Sakurada, S. Furuta, K. Chaki, K. Kisara, Y. Sasaki, K. Suzuki: Opioid activities of D-Arg2-substituted tetrapeptides. J. Pharmacol. Exp. Ther. 242: 654-659, 1987.
39. T. Sakurada, H. Kuwahara, S. Sakurada, K. Kisara, M. Ohba, E. Munekata: Behavioural assessment as substance P antagonists in mice. Neuropeptides 9: 197-206, 1987.
40. G. Bagetta, M.T. Corasaniti, M.C. Strongoli, S. Sakurada, G. Nistico: Electrocortical spectrum power effects of different classes of neuroleptics in rats. J. Psychiatr. Res. 21: 93-99, 1987.
41. H. Kuwahara, T. Sakurada, S. Sakurada, A. Yonezawa, R. Ando, K. Kisara, F. Osakada, E. Munekata: Behavioural effects of intrathecally injected tachykinins in rats with peripheral nerve transection. Naunyn-Schmiedeberg’s Arch. Pharmacol. 336: 656-660, 1987.
42. K. Chaki, S. Kawamura, K. Kisara, S. Sakurada, T. Sakurada, Y. Sasaki, T. Sato, K. Suzuki: Antinociception and physical dependence produced by [D-Arg2]dermorphin tetrapeptide analogues and morphine in rats. Br. J. Pharmacol. 95: 15-22, 1988.
43. T. Sakurada, K. Takahashi, S. Sakurada, K. Kisara, R. Folkesson, L. Terenius: Enkephalins interact with substance P-induced aversive behaviour in mice. Brain Res. 442: 191-194, 1988.
44. T. Sakurada, H. Kuwahara, K. Takahashi, S. Sakurada, K. Kisara, L. Terenius: Substance P(1-7) antagonizes substance P-induced aversive behaviour in mice. Neurosci. Lett. 95: 281-285, 1988.
45. K. Chaki, S. Sakurada, T. Sakurada, T. Sato, S. Kawamura, K. Kisara, H. Watanabe, K. Suzuki: Comparison of the antinociceptive effects of new [D-Arg2]-dermorphin tetrapeptide analogs and morphine in mice. Pharmacol. Biochem. Behav. 31: 439-444, 1988.
46. K. Suzuki, H. Fujita, Y. Sasaki, M. Shiratori, S. Sakurada, K. Kisara: Studies on analgesic oligopeptides. V. Structure-activity relationship of tripeptide alkylamides, Tyr-D-Arg-Phe-X. Chem. Pharm. Bull. 36: 4834-4840, 1988.
47. K. Chaki, S. Sakurada, T. Sakurada, T. Sato, S. Kawamura, K. Kisara, Y. Sasaki, K. Suzuki: A new class opioid peptide, [D-Arg2,b-Ala4]-dermorphin tetrapeptide; physical dependence liability in mice. Neuropeptides 13: 83-88, 1989.
48. T. Sakaurada, T. Yamada, S. Sakurada, K. Kisara, M. Ohba: Substance P analogues containing D-histidine antagonize the behavioural effects of intrathecally co-administered substance P in mice. Eur. J. Pharmacol. 174: 153-160, 1989.
49. K. Chaki, S. Sakurada, T. Sakurada, K. Kisara, K. Suzuki: N-terminal tetrapeptide of dermorphin and D-Arg-substituted tetrapeptides: inactivation process of the antinociceptive activity by peptidase. Life Sci. 46: 1671-1678, 1990.
50. K. Chaki, S. Sakurada, T. Sakurada, N. Nakata, K. Kisara, H. Watanabe, K. Suzuki: Antinociceptive cross-tolerance between [D-Arg2]-dermorphin tetrapeptide analogs and morphine. Peptides 11: 139-144, 1990.
51. T. Sakurada, Y. Manome, K. Tan-No, S. Sakurada, K. Kisara: The effects of substance P analogues on the scratching, biting and licking response induced by intrathecal injection of N-methyl-D-aspartate in mice. Br. J. Pharmacol. 101: 307-310, 1990.
52. T. Sakurada, K. Tan-No, T. Yamada, S. Sakurada, K. Kisara: Phosphoramidon potentiates mammalian tachykinin-induced biting, licking and scratching behaviour in mice. Pharmacol. Biochem. Behav. 37: 779-783,1990.
53. T. Sakurada, K. Tan-No, T. Yamada, S. Sakurada, K. Kisara, M. Ohba, L. Terenius: N-terminal substance P fragments inhibit the spinally induced, NK 1 receptor mediated behavioural responses in mice. Life Sci. 47: PL109-113, 1990.
54. T. Otsuki, Y. Agatsuma, H. Jokura, S. Sakurada, K. Kisara, T. Yoshimoto: Monosodium urate test: a new analgesic test by crystal-induced monoarthritis in rats. J. Neurosci. Methods 33: 229-231, 1990.
55. G. Bagetta, G.B. De Sarro, S. Sakurada, V. Rispoli, G. Nistico: Different profile of electrocortical power spectrum changes after micro-infusion into the locus coeruleus of selective agonists at various opioid receptor subtypes in rats. Br. J. Pharmacol. 101: 655-661, 1990.
56. N. Nakata, S. Sakurada, T. Sakurada, S. Kawamura, K. Kisara, K. Suzuki: Spinal antinociception: comparison of a dermorphin tetrapeptide analogue, [D-arginine2, sarcosine4]-dermorphin (1-4) and morphine in rats. Neuropharmacology 29: 337-341, 1990.
57. T. Sakurada, A. Hara, H. Matsumura, H. Yamada, S. Sakurada, K. Kisara: A substance P analogue reduces amino acid contents in the rat spinal cord. Pharmacol. Toxicol. 66: 75-76, 1990.
58. T. Sakurada, K. Tan-no, T. Yamada, Y. Manome, S. Kawamura, A. Yonezawa, R. Ando, S. Sakurada, K. Kisara: Pharmacological characterization of a tachykinin antagonist, spantide, as examined by the spinally mediated scratching behaviour. Neuropeptides (Life Sci. Adv.) 10: 35-40, 1991.
59. T. Sakurada, T. Yamada, K. Tan-no, Y. Manome, S. Sakurada, K. Kisara, M. Ohba: Differential effects of substance P analogs on neurokinin 1 receptor agonists in the mouse spinal cord. J. Pharmacol. Exp. Ther. 259: 205-210, 1991.
60. S. Sakurada, H. Watanabe, T. Sakurada, K. Kisara, Y. Sasaki, K. Suzuki: Different effects of peptidase inhibitors on dermorphin- and on [D-Arg2]dermorphin-induced antinociceptive activity. Eur. J. Pharmacol. 211: 75-80, 1992.
61. T. Sakurada, Y. Manome, K. Katsumata, H. Uchiumi, K. Tan-No, S. Sakurada, K. Kisara: Naloxone-reversible effect of spantide on the spinally mediated behavioural response induced by neurokinin-2 and -3 receptor agonists. Naunyn-Schmiedeberg’s Arch. Pharmacol. 346: 69-75, 1992.
62. T. Sakurada, Y. Manome, K. Tan-No, S. Sakurada, K. Kisara, M. Ohba, L. Terenius: A selective and extremely potent antagonist of the neurokinin-1 receptor. Brain Res. 593: 319-322, 1992.
63. T. Sakurada, K. Katsumata, K. Tan-No, S. Sakurada, K. Kisara: The capsaicin test in mice for evaluating tachykinin antagonists in the spinal cord. Neuropharmacology 31: 1279-1285, 1992.
64. T. Sato, S. Sakurada, T. Sakurada, K. Kisara, K. Suzuki: Comparison of opioid properties between D-Arg-containing dipeptides and tetrapeptides. Biochem. Pharmacol. 43: 717-723, 1992.
65. S. Sakurada, K. Chaki, H. Watanabe, N. Nakata, T. Sakurada, K. Kisara, K. Suzuki: Antinociceptive mechanisms of [D-Arg2]-dermorphin tripeptide analogs. J. Pharmacol. Exp. Ther. 263: 793-799, 1992.
66. S. Sakurada, N. Nakata, T. Sakurada, K. Chaki, S. Kawamura, K. Kisara, K. Suzuki: Tolerance and cross-tolerance to the antinociceptive effects of [D-Arg2]-dermorphin tetrapeptide analogue and morphine. Neuropharmacology 32: 689-693, 1993.
67. T. Sakurada, K. Katsumata, H. Yogo, K. Tan-No, S. Sakurada, K. Kisara: Antinociception induced by CP 96,345, a non-peptide NK-1 receptor antagonist, in the mouse formalin and capsaicin tests. Neurosci. Lett. 151: 142-145, 1993.
68. T. Sakurada, Y. Manome, K. Tan-No, Y. Matsunaga, S. Sakurada, K. Kisara: Possible involvement of the spinal substance P system in pilocarpine-induced scratching in mice. Pharmacol. Biochem. Behav. 44: 439-445, 1993.
69. T. Sakurada, K. Katsumata, Y. Manome, K. Tan-No, S. Sakurada, K. Kisara, M. Ohba: Antinociceptive effects in the formalin and capsaicin tests after intrathecal administration of substance P analogues in mice. Eur. J. Pharmacol. 242: 47-52, 1993.
70. H. Nagaoka, S. Sakurada, T. Sakurada, S. Takeda, Y. Nakagawa, K. Kisara, Y. Arai: Theophylline-induced nociceptive behavioral response in mice: possible indirect interaction with spinal N-methyl-D-aspartate receptors. Neurochem. Int. 22: 69-74, 1993.
71. T. Sakurada, Y. Manome, K. Tan-No, S. Sakurada, M. Ohba, K. Kisara, L. Terenius: A selective and extremely potent antagonist of the neurokinin-1 receptor. Regul. Pept. 46: 326-328, 1993.
72. K. Tan-No, T. Sakurada, T. Yamada, S. Sakurada, K. Kisara: Spantide-induced antinociception in the opioid mechanism. Regul. Pept. 46: 343-345, 1993.
73. T. Sakurada, H. Yogo, K. Tan-No, S. Sakurada, K. Kisara: Behavioral activation of neurokinin-1 agonists in relation to enzymatic degradation in the spinal cord. J. Pharm. Sci. 83: 2-4, 1994.
74. T. Sakurada, H. Yogo, K. Katsumata, K. Tan-No, S. Sakurada, K. Kisara, M. Ohba: Differential antinociceptive effects of sendide, a NK1-receptor antagonist, and morphine in the capsaicin test. Brain Res. 649: 319-322, 1994.
75. T. Sakurada, Y. Manome, K. Katsumata, K. Tan-No, S. Sakurada, M. Ohba, K. Kisara: Comparison of antagonistic effects of sendide and CP-96,345 on a spinally mediated behavioural response in mice. Eur. J. Pharmacol. 261: 85-90, 1994.
76. T. Sakurada, H. Yogo, Y. Manome, K. Tan-No, S. Sakurada, A. Yamada, K. Kisara, M. Ohba: Pharmacological characterisation of NK1 receptor antagonist, [D-Trp7]sendide, on behaviour elicited by substance P in the mouse. Naunyn-Schmiedeberg’s Arch. Pharmacol. 350: 387-392, 1994.
77. T. Sakurada, K. Ktsumata, H. Yogo, K. Tan-No, S. Sakurada, M. Ohba, K. Kisara: The neurokinin-1 receptor antagonist, sendide, exhibits antinociceptive activity in the formalin test. Pain 60: 175-180, 1995.
78. T. Tadano, T. Asao, T. Aizawa, S. Sakurada, Y. Abe, A. Yonezawa, R. Ando, Y. Arai, H. Kinemuchi, K. Kisara: Immunohistochemical determination of rat spinal cord substance P, and antinociceptive effect during development of thiamine deficiency. Brain Res. 696: 21-29, 1995.
79. S. Sakurada, T. Sato, N. Takahashi, S. Kawamura, K. Tan-No, T. Sakurada, T. Tadano, T. Fujimura, K. Murayama, K. Kisara: Role of mu-1 opioid receptor subtype on morphine-induced antinociception against responses to mechanical and chemical noxious stimuli in mice. Neurosciences 21: 115-121, 1995.
80. K. Tan-No, T. Sakurada, T. Yamada, S. Sakurada, K. Kisara: Involvement of opioid receptors in the antinociception produced by intracerebroventricularly administered spantide in mice. Neuropeptides 29: 293-299, 1995.
81. T. Sakurada, A. Sugiyama, C. Sakurada, K. Tan-No, A. Yonezawa, S. Sakurada, K. Kisara: Effect of spinal nitric oxide inhibition on capsaicin-induced nociceptive response. Life Sci. 59: 921-930, 1996.
82. T. Sakurada, A. Sugiyama, C. Sakurada, K. Tanno, S. Sakurada, K. Kisara, A. Hara, Y. Abiko: Involvement of nitric oxide in spinally mediated capsaicin- and glutamate-induced behavioural responses in the mouse. Neurochem. Int. 29: 271-278, 1996.
83. T. Sakurada, K. Wako, C. Sakurada, Y. Manome, K. Tan-no, S. Sakurada, K. Kisara: Spinally-mediated behavioural responses evoked by intrathecal high-dose morphine: possible involvement of substance P in the mouse spinal cord. Brain Res. 724: 213-221, 1996.
84. K. Tan-No, A. Taira, T. Sakurada, M. Inoue, S. Sakurada, T. Tadano, T. Sato, C. Sakurada, I. Nylander, J. Silberring, L. Terenius, K. Kisara: Inhibition of dynorphin-converting enzymes prolongs the antinociceptive effect of intrathecally administered dynorphin in the mouse formalin test. Eur. J. Pharmacol. 314: 61-67, 1996.
85. N. Nakata, S. Sakurada, T. Sakurada, K. Tan-No, K. Kisara: Comparison of effect of [D-Arg2,Sar4]-dermorphin (1-4) and morphine on mouse small intestinal transit and electrically evoked contraction of guinea pig ileum. Methods Find. Exp. Clin. Pharmacol. 20: 193-198, 1998.
86. T. Sato, N. Takahashi, K. Tan-No, K. Kisara, T. Sakurada, S. Sakurada: Comparison of opioid activity between a N-terminal tetrapeptide analogue of dermorphin, H-Tyr-D-Arg-Phe-b-Ala-OH and morphine. Methods Find. Exp. Clin. Pharmacol. 20: 581-586, 1998.
87. K. Kakizawa, I. Shimohira, S. Sakurada, T. Fujimura, K. Murayama, H. Ueda: Parallel stimulations of in vitro and in situ [35S]GTPgS binding by endomorphin 1 and DAMGO in mouse brains. Peptides 19: 755-758, 1998.
88. T. Sato, S. Sakurada, N. Takahashi, T. Sakurada, K. Tan-No, K. Wako, K. Kisara: Contribution of spinal m1-opioid receptors to morphine-induced antinociception. Eur. J. Pharmacol. 369: 183-187, 1999.
89. T. Sakurada, M. Yuhki, M. Inoue, C. Sakurada, K. Tan-No, M. Ohba, K. Kisara, S. Sakurada: Opioid activity of sendide, a tachykinin NK1 receptor antagonist. Eur. J. Pharmacol. 369: 261-266, 1999.
90. C. Sakurada, S. Sakurada, S. Katsuyama, J. Sasaki, K. Tan-No, T. Sakurada: Involvement of tachykinin NK1 receptors in nociceptin-induced hyperalgesia in mice. Brain Res. 841: 85-92, 1999.
91. C. Sakurada, C. Watanabe, S. Sakurada, K. Tan-No, T. Sakurada: Major metabolites of substance P degraded by spinal synaptic membranes antagonize the behavioral response to substance P in rats. J. Pharm. Sci. 88: 1127-1132, 1999.
92. S. Sakurada, K. Onodera, S. Katsuyama, A. Yonezawa, K. Arai, T. Hayashi, S. Furuta, T. Sato, K. Kisara: Effects of forced walking stress on formalin-induced paw licking in mice. Methods Find. Exp. Clin. Pharmacol. 21: 467-470, 1999.
93. O. Nakagawasai, T. Tadano, K. Tan-No, F. Niijima, S. Sakurada, Y. Endo, K. Kisara: Changes in b-endorphin and stress-induced analgesia in mice after exposure to forced walking stress. Methods Find. Exp. Clin. Pharmacol. 21: 471-476, 1999.
94. S. Sakurada, J.E. Zadina, A.J. Kastin, S. Katsuyama, T. Fujimura, K. Murayama, M. Yuki, H. Ueda, T. Sakurada: Differential involvement of m-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception. Eur. J. Pharmacol. 372: 25-30, 1999.
95. T. Sakurada, S. Katsuyama, S. Sakurada, M. Inoue, K. Tan-No, K. Kisara, C. Sakurada, H. Ueda, J. Sasaki: Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors. Br. J. Pharmacol. 127: 1712-1718, 1999.
96. T. Sakurada, S. Sakurada, S. Katsuyama, C. Sakurada, K. Tan-No, L. Terenius: Nociceptin (1-7) antagonizes nociceptin-induced hyperalgesia in mice. Br. J. Pharmacol. 128: 941-944, 1999.
97. M. Nakamura, Y.M. Chi, W.M. Yan, Y. Nakasugi, T. Yoshizawa, N. Irino, F. Hashimoto, J. Kinjo, T. Nohara, S. Sakurada: Strong antinociceptive effect of incarvillateine, a novel monoterpene alkaloid from Incarvillea sinensis. J. Nat. Prod. 62: 1293-1294, 1999.
98. J.I. Mobarakeh, S. Sakurada, S. Katsuyama, M. Kutsuwa, A. Kuramasu, Z.Y. Lin, T. Watanabe, Y. Hashimoto, K. Yanai: Role of histamine H1 receptor in pain perception: a study of the receptor gene knockout mice. Eur. J. Pharmacol. 391: 81-89, 2000.
99. S. Sakurada, S. Takeda, T. Sato, T. Hayashi, M. Yuki, M. Kutsuwa, K. Tan-No, C. Sakurada, K. Kisara, T. Sakurada: Selective antagonism by naloxonazine of antinociception by Tyr-D-Arg-Phe-b-Ala, a novel dermorphin analogue with high affinity at m-opioid receptors. Eur. J. Pharmacol. 395: 107-112, 2000.
100. F. Niijima, K. Tan-No, A. Esashi, O. Nakagawasai, T. Tadano, N. Takahashi, A. Yonezawa, S. Sakurada, K. Kisara: Inhibitory effect of intracerebroventricularly-administered [D-Arg2,b-Ala4]-dermorphin (1-4) on gastrointestinal transit. Peptides 21: 295-299, 2000.
101. A. Yonezawa, C. Watanabe, R. Ando, S. Furuta, S. Sakurada, H. Yoshimura, T. Iwanaga, Y. Kimura: Characterization of p-chloroamphetamine-induced penile erection and ejaculation in anesthetized rats. Life Sci. 67: 3031-3039, 2000.
102. K. Onodera, S. Sakurada, S. Furuta, A. Yonezawa, K. Arai, T. Hayashi, S. Katsuyama, T. Sato, S. Miyazaki, K. Kisara: Differential involvement of opioid receptors in stress-induced antinociception caused by repeated exposure to forced walking stress in mice. Pharmacology 61: 96-100, 2000.
103. S. Sakurada, T. Hayashi, M. Yuhki, T. Fujimura, K. Murayama, A. Yonezawa, C. Sakurada, M. Takeshita, J.E. Zadina, A.J. Kastin, T. Sakurada: Differential antagonism of endomorphin-1 and endomorphin-2 spinal antinociception by naloxonazine and 3-methoxynaltrexone. Brain Res. 881: 1-8, 2000.
104. T. Sakurada, S. Sakurada, S. Katsuyama, T. Hayashi, C. Sakurada, K. Tan-No, H. Johansson, J. Sandin, L. Terenius: Evidence that N-terminal fragments of nociceptin modulate nociceptin-induced scratching, biting and licking in mice. Neurosci. Lett. 279: 61-64, 2000.
105. C. Sakurada, A. Sugiyama, M. Nakayama, A. Yonezawa, S. Sakurada, K. Tan-No, K. Kisara, T. Sakurada: Antinociceptive effect of spinally injected L-NAME on the acute nociceptive response induced by low concentrations of formalin. Neurochem. Int. 38: 417-423, 2001.
106. A. Yonezawa, R. Ando, C. Watanabe, S. Furuta, M. Kutsuwa, S. Sakurada, Y. Kimura: a2-Adrenoceptor antagonists: effects on ejaculation, penile erection and pelvic thrusting behavior in dogs. Pharmacol. Biochem. Behav. 70: 141-147, 2001.
107. S. Sakurada, T. Hayashi, M. Yuhki, T. Orito, J.E. Zadina, A.J. Kastin, T. Fujimura, K. Murayama, C. Sakurada, T. Sakurada, M. Narita, T. Suzuki, K. Tan-no, L.F. Tseng: Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse. Eur. J. Pharmacol. 427: 203-210, 2001.
108. M. Nakamura, Y.M. Chi, W.M. Yan, A. Yonezawa, Y. Nakasugi, T. Yoshizawa, F. Hashimoto, J. Kinjo, T. Nohara, S. Sakurada: Structure-antinociceptive activity studies of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis. Planta. Med. 67: 114-117, 2001.
109. K. Onodera, S. Sakurada, S. Furuta, A. Yonezawa, T. Hayashi, I. Honma, S. Miyazaki: Age-related differences in forced walking stress-induced analgesia in mice. Drugs Exp. Clin. Res. 27: 193-198, 2001.
110. S. Sakurada, T. Orito, C. Sakurada, T. Sato, T. Hayashi, J.I. Mobarakeh, K. Yanai, K. Onodera, T. Watanabe, T. Sakurada: Possible involvement of tachykinin NK1 and NMDA receptors in histamine-induced hyperalgesia in mice. Eur. J. Pharmacol. 434: 29-34, 2002.
111. T. Sakurada, C. Watanabe, K. Okuda, A. Sugiyama, T. Moriyama, C. Sakurada, K. Tan-No, S. Sakurada: Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors. Mol. Brain Res. 98: 111-118, 2002.
112. K. Onodera, A. Takahashi, S. Sakurada, Y. Okano: Effects of phenytoin and/or vitamine K2 (menatetrenone) on bone mineral density in the tibiae of growing rats. Life Sci. 70: 1533-1542, 2002.
113. T. Ogawa, T. Miyamae, T. Okayama, M. Hagiwara, S. Sakurada, T. Morikawa: Structure-activity relationships (SAR) of [D-Arg2]dermorphin(1-4) analogues, Na-amidino-Tyr-D-Arg-Phe-X. Chem. Pharm. Bull. 50: 771-780, 2002.
114. S. Sakurada, T. Hayashi, M. Yuhki, T. Fujimura, K. Murayama, A. Yonezawa, C. Sakurada, M. Takeshita, T. Sato, J.E. Zadina, A.J. Kastin, T. Sakurada: Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone. Peptides 23: 895-901, 2002.
115. J.I. Mobarakeh, S. Sakurada, T. Hayashi, T. Orito, K. Okuyama, T. Sakurada, A. Kuramasu, T. Watanabe, T. Watanabe, K. Yanai: Enhanced antinociception by intrathecally-administered morphine in histamine H1 receptor gene knockout mice. Neuropharmacology 42: 1079-1088, 2002.
116. M. Narita, S. Sakurada: Recent advances in the search for the m-opioidergic system. Jpn. J. Pharmacol. 89: 201-202, 2002.
117. S. Sakurada, T. Hayashi, M. Yuhki: Differential antinociceptive effects induced by intrathecally-administered endomorphin-1 and endomorphin-2 in mice. Jpn. J. Pharmacol. 89: 221-223, 2002.
118. C. Sakurada, S. Sakurada, T. Orito, K. Tan-No, T. Sakurada: Degradation of nociceptin (orphanin FQ) by mouse spinal cord synaptic membranes is triggered by endopeptidase-24.11: an in vitro and in vivo study. Biochem. Pharmacol. 64: 1293-1303, 2002.
119. K.-C. Hung, H.-E. Wu, H. Mizoguchi, S. Sakurada, T. Okayama, T. Fujimura, K. Murayama, T. Sakurada, J.M. Fujimoto, L.F. Tseng: D-Pro2-endomorphin-1 and D-Pro2-endomorphin-2 respectively attenuate the antinociception induced by endomorphin-1 and endomorphin-2 given intrathecally in the mouse. J. Pharmacol. Exp. Ther. 303: 874-879, 2002.
120. T. Ogawa, T. Miyamae, K. Murayama, K. Okuyama, T. Okayama, M. Hagiwara, S. Sakurada, T. Morikawa: Synthesis and structure-activity relationships of an orally-available and long-acting analgesic peptide, Na-amidino-Tyr-D-Arg-Phe-MebAla-OH (ADAMB). J. Med. Chem. 45: 5081-5089, 2002.
121. S. Sakurada, H. Watanabe, T. Hayashi, M. Yuhki, T. Fujimura, K. Maruyama, C. Sakurada, T. Sakurada: Endomorphin analogues containing D-Pro2 discriminate different m-opioid receptor mediated antinociception in mice. Br. J. Pharmacol. 137: 1143-1146, 2002.
122. S. Sakurada, T. Orito, S. Furuta, H. Watanabe, J.I. Mobarakeh, K. Yanai, T. Watanabe, T. Sato, K. Onodera, C. Sakurada, T. Sakurada: Intrathecal histamine induces spinally-mediated behavioral responses through tachykinin NK1 receptors. Pharmacol. Biochem. Behav. 74: 487-493, 2003.
123. M. Narita, M. Suzuki, H. Mizoguchi, M. Narita, Y. Yajima, S. Sakurada, L.F. Tseng, T. Suzuki: Up-regulation of m-opioid receptor-mediated G-protein activation in protein kinase Cg knockout mice following repeated naloxone treatment. Neurosci. Lett. 338: 103-106, 2003.
124. Y. Deguchi, Y. Miyakawa, S. Sakurada, Y. Naito, K. Morimoto, S. Ohtsuki, K.-I. Hosoya, T. Terasaki: Blood-brain barrier transport of a novel m1-specific opioid peptide, H-Tyr-D-Arg-Phe-b-Ala-OH (TAPA). J. Neurochem. 84: 1154-1161, 2003.
125. K. Onodera, A. Takahashi, H. Wakabayashi, J. Kamei, S. Sakurada: Effects of menatetrenone on the bone and serum levels of vitamin K2 (menaquinone derivatives) in osteopenia induced by phenytoin in growing rats. Nutrition 19: 446-450, 2003.
126. A. Takahashi, K. Onodera, J. Kamei, S. Sakurada, H. Shinoda, S. Miyazaki, T. Saito, H. Mayanagi: Effects of chronic administration of zonisamide, an antiepileptic drug, on bone mineral density and their prevention with alfacalcidol in growing rats. J. Pharmacol. Sci. 91: 313-318, 2003.
127. J.I. Mabarakeh, J.W. Nalwalk, T. Watanabe, S. Sakurada, M. Hoffman, R. Leurs, H. Timmerman, I. Silos-Santiago, K. Yanai, L.B. Hough: Improgan antinociception does not require neuronal histamine or histamine receptors. Brain Res. 974: 146-152, 2003.
128. T. Sakurada, T. Matsumura, T Moriyama, C. Sakurada, S. Ueno, S. Sakurada: Differential effects of intraplantar capsazepine and ruthenium red on capsaicin-induced desensitization in mice. Pharmacol. Biochem. Behav. 75: 115-121, 2003.
129. A. Yonezawa, M. Kutsuwa, T. Amano, Y. Kimura, S. Sakurada: Comparison of the effects of yohimbine, naloxone and 8-OH-DPAT on the diminished ejaculatory capacity induced by repeated ejaculation. Biomed. Res. 24: 71-75, 2003.
130. T. Ogawa, M. Araki, T. Miyamae, T. Okayama, M. Hagiwara, S. Sakurada, T. Morikawa: Synthesis and antinociceptive activity of orally active opioid peptides: Improvement of oral bioavailability by esterification. Chem. Pharm. Bull. 51: 759-771 2003.
131. T. Sato, H. Watanabe, S. Furuta, J. Terui, D. Nakayama, K. Onodera, S. Satoh, S. Sakurada: Involvement of spinal m-opioid receptor subtypes in stress-induced antinociception caused by repeated exposure to forced walking stress in mice. Oyo Yakuri/Pharmacometrics 65: 11-15 2003.
132. C. Sakurada, S. Sakurada, T. Hayashi, S. Katsuyama, K. Tan-No, T. Sakurada: Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: an in vitro and in vivo study. Biochem. Pharmacol. 66: 653-661 2003.
133. C. Watanabe, K. Okuda, C. Sakurada, R. Ando, T. Sakurada, S. Sakurada: Evidence that nitric oxide-glutamate cascade enhances spinal antinociceptive effect of morphine: a behavioural and microdialysis study in rats. Brain Res. 990: 77-86, 2003.
134. C. Watanabe, T. Sakurada, K. Okuda, C. Sakurada, R. Ando, S. Sakurada: The role of spinal nitric oxide and glutamate in nociceptive behaviour evoked by high-dose intrathecal morphine in rats. Pain 106: 269-283, 2003.
135. S. Furuta, K. Onodera, M. Kumagai, I. Honma, S. Miyazaki, S. Sato, S. Sakurada: Involvement of adenosine A1 receptors in forced walking stress-induced analgesia in mice. Methods Find. Exp. Clin. Pharmacol. 25: 793-796, 2003.
136. K. Uwai, H. Uchiyama, S. Sakurada, C. Kabuto, M. Takeshita: Syntheses and receptor-binding studies of derivatives of the opioid antagonist naltrexone. Bioorg. Med. Chem. 12: 417-421, 2004.
137. H. Mizoguchi, M. Yuhki, H. Watanabe, T. Hayashi, C. Sakurada, A. Yonezawa, T. Sakurada, S. Sakurada: Differential involvement of m1 receptor on dermorphin tetrapeptide analogues-induced antinociception. Eur. J. Pharmacol. 486: 19-24, 2004.
138. A. Yonezawa, R. Ando, M. Imai, C. Watanabe, S. Furuta, M. Kutsuwa, Y. Kimura, S. Sakurada: Differential effects of yohimbine, naloxone and 8-OH-DPAT on ejaculatory response in male dogs. Methods Find. Exp. Clin. Pharmacol. 26: 47-51, 2004.
139. Y. Deguchi, Y. Naito, S. Ohtsuki, Y. Miyakawa, K. Morimoto, K.-I. Hosoya, S. Sakurada, T. Terasaki: Blood-brain barrier permeability of novel [D-Arg2]dermorphin (1-4) analogues: transport property is related to the slow onset of antinociceptive activity in the central nervous system. J. Pharmacol. Exp. Ther. 310: 177-184 2004.
140. S. Sakurada, H. Watanabe, H. Mizoguchi, A. Yonezawa, T. Orito, S. Katsuyama, A. Kuramasu, C. Sakurada, K. Yanai, T. Sakurada: Involvement of the histaminergic system in the nociceptin-induced pain-related behaviors in the mouse spinal cord. Pain 112: 171-182, 2004.
141. K. Ohinata, T. Shimano, R. Yamauchi, S. Sakurada, K. Yanai, M. Yoshikawa: The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice. Peptides 25: 2135-2138, 2004.
142. H. Ouchi, M. Kumagai, S. Sakurada, H. Takahata: Asymmetric synthesis of all six regioisomers of N-boc-dimethylphenylalanines. Heterocycles 64: 505-514, 2004.
143. K. Tan-No, H. Takahashi, O. Nakagawasai, F. Niijima, T. Sato, S. Satoh, S. Sakurada, Z. Marinova, T. Yakovlsva, G. Bakalkin L. Terenius, T. Tadano: Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation. Pain 113: 301-309, 2005.
144. H. Watanabe, D. Nakayama, K. Ito, C. Watanabe, H. Mizoguchi, T. Fujimura, K. Murayama, S. Kawamura, T. Sato, C. Sakurada, T. Sakurada, S. Sakurada: A Tyr-W-MIF-1 analogue containing D-Pro2 acts as a selective m2-opioid receptor antagonist in the mouse. J. Pharmacol. Exp. Ther. 312: 1075-1081, 2005.
145. J.I. Mobarakeh, K. Takahashi, S. Sakurada, S. Nishino, H. Watanabe, M. Kato, K. Yanai: Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and -2) in mice. Peptides 26: 767-777, 2005.
146. Y. Kitano, C. Komiyama, M. Makino, K. Takesuna, A. Takazawa, S. Sakurada: Anticonvulsant properties of the novel nootropic agent nefiracetam seizure models of mice and rats. Epilepsia 46: 811-818, 2005.
147. Y.M. Chi, M. Nakamura, T. Yoshizawa, X.Y. Zhao, W.M. Yan, F. Hashimoto, J. Kinjo, T. Nohara, S. Sakurada: Anti-inflammatory activities of alpha-truxillic acid derivatives and their monomer components. Biol. Pharm. Bull. 28: 1776-1778, 2005.
148. Y. Kitano, C. Komiyama, M. Makino, K. Takasuna, H. Satoh, T. Aoki, M. Kinoshita, A. Takazawa, T. Yamauchi, S. Sakurada: Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats. Brain Res. 1057: 168-176, 2005.
149. Y. Kitano, C. Komiyama, M. Makino, Y. Kasai, K. Takasuna, M. Kinoshita, O. Yamazaki, A. Takazawa, T. Yamauchi, S. Sakurada: Effects of nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats. Epilepsia 46: 1561-1568, 2005.
150. Y.M. Chi, M. Nakamura, T. Yoshizawa, X.Y. Zhao, W.M. Yan, F. Hashimoto, J. Kinjo, T. Nohara, S. Sakurada: Pharmacological study on the novel antinociceptive agent, a novel monoterpene alkaloid from incarvillea sinensis. Biol. Pharm. Bull. 28: 1989-1991, 2005.
151. A. Yoshida, J.I. Mobarakeh, E. Sakurai, S. Sakurada, T. Orito, A. Kuramasu, M. Kato, K. Yanai: Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: A study in histidine decarboxylase gene knockout mice. Eur. J. Pharmacol. 522: 55-62, 2005.
152. T. Sakurada, T. Komatsu, S. Sakurada: Mechanisms of nociception evoked by intrathecal high-dose morphin. Neurotoxicology 26: 801-809, 2005.
153. J.I. Mobarakeh, K. Takahashi, S. Sakurada, S. Nishino, H. Watanabe, M. Kato, N. Naghdi, K. Yanai: Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice. Pain 118: 254-262, 2005.
154. A. Yonezawa, M. Yoshizumi, M. Ebiko, T. Amano, Y. Kimura, S. Sakurada: Long-lasting effects of yohimbine on the ejaculatory function in male dogs. Biomed. Res. 26: 201-206, 2005.
155. T. Sakurada, T. Komatsu, T. Moriyama, M. Sasaki, K. Sanai, T. Orito, C. Sakurada, S. Sakurada: Effects of intraplantar injections of nociceptin and its N-terminal fragments on nociceptive and desensitized responses induced by capsaicin in mice. Peptides 26: 2505-2512, 2005.
156. A. Yonezawa, M. Yoshizumi, M. Ebiko, T. Iwanaga, Y. Kimura, S. Sakurada: Evidence for an involvement of peripheral serotonin in p-chloroamphetamine-induced ejaculation of rats. Pharmacol. Biochem. Behav. 82: 744-750, 2005.
157. Y.M. Chi, M. Nakamura, X.Y. Zhao, T. Yoshizawa, W.M. Yan, F. Hashimoto, J. Kinjo, T. Nohara, S. Sakurada: Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid. Biol. Pharm. Bull. 29: 489-493, 2006.
158. Y.M. Chi, M. Nakamura, X.Y. Zhao, T. Yoshizawa, W.M. Yan, F. Hashimoto, J. Kinjo, T. Nohara, S. Sakurada: Antinociceptive activities of alpha-truxillic acid and beta-truxinic acid derivatives. Biol. Pharm. Bull. 29: 580-584, 2006.
159. H. Mizoguchi, H. Watanabe, T. Hayashi, W. Sakurada, T. Sawai, T. Fujimura, T. Sakurada, S. Sakurada: Possible involvement of dynorphin A (1-17) release via m1-opioid receptors in spinal antinociception by endomorphin-2. J. Pharmacol. Exp. Ther. 317: 362-368, 2006.
160. H. Watanabe, D. Nakayama, M. Yuhki, T. Sawai, W. Sakurada, S. Katsuyama, T. Hayashi, C. Watanabe, H. Mizoguchi, T. Fujimura, T. Sakurada, S. Sakurada: Differential inhibitory effects of m-opioids on substance P- and capsaicin-induced nociceptive behavior in mice. Peptides 27: 760-768, 2006.
161. H. Mizoguchi, D. Nakayama, H. Watanabe, K. Ito, W. Sakurada, T. Sawai, T. Fujimura, T. Sato, T. Sakurada, S. Sakurada: Involvement of spinal m1-opioid receptors on the Tyr-D-Arg-Phe-sarcosin-induced antinociception. Eur. J. Pharmacol. 540: 67-72, 2006.
162. J.I. Mobarakeh, K. Takahashi, S. Sakurada, A. Kuramasu, K Yanai: Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice. Neuropharmacology 51: 612-622, 2006.
163. H. Mizoguchi, K. Ito, H. Watanabe, C. Watanabe, S. Katsuyama, T. Fujimura, T. Sakurada, S. Sakurada: Contribution of spinal m1-opioid receptors and dynorphin B to the antinociception induced by Tyr-D-Arg-Phe-Sar. Peptides 27: 2786-2793, 2006.
164. K. Okuyama, K. Ohwada, S. Sakurada, N. Sato, I. Sora, G. Tamura, M. Takayanagi, I. Ohno: The distinctive effects of acute and chronic psychological stress on airway inflammation in a murine model of allergic asthma. Allergol. Int. 56: 29-35 2007.
165. H. Watanabe, H. Mizoguchi, T. Orito, S. Katsuyama, A. Yonezawa, C. Watanabe, T. Sakurada, S. Sakurada: Possible involvement of endogenous nociceptin/orphanin FQ in the pain-related behavioral responses induced by its own metabolite, nociceptin/orphanin FQ(14-17). Peptides 28: 670-677, 2007.
166. H. Mizoguchi, C. Watanabe, H. Watanabe, K. Moriyama, B. Sato, K. Ohwada, A. Yonezawa, T. Sakurada, S. Sakurada: Involvement of endogenous opioid peptides in the antinociception induced by the novel dermorphin tetrapeptide analog amidino-TAPA. Eur. J. Pharmacol. 560: 150-159, 2007.
167. T. Komatsu, C. Sakurada, M. Sasaki, K. Sanai, M. Tsuzuki, G. Bagetta, S. Sakurada, T. Sakurada: Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior. Neuropharmacology 52: 1237-1243, 2007.
168. D. Nakayama, H. Watanabe, C. Watanabe, H. Mizoguchi, T. Sakurada, S. Sakurada: A Tyr-W-MIF-1 analog containing D-Pro2 discriminates among antinociception in mice mediated by different classes of m-opioid receptors. Eur. J. Pharmacol. 563: 109-116, 2007.
169. T. Sakurada, T. Komatsu, H. Kuwahata, C. Watanabe, T. Orito, C. Sakurada, M. Tsuzuki, S. Sakurada: Intrathecal substance P (1-7) prevents morphine-evoked spontaneous pain behavior via spinal NMDA-NO cascade. Biochem. Pharmacol. 74: 758-767, 2007.
170. A. Yonezawa, M. Yoshizumi, M. Ebiko, S.N. Ise, C. Watanabe, H. Mizoguchi, Y. Kimura, S. Sakurada: Ejaculatory response induced by a 5-HT2 receptor agonist m-CPP in rats: Differential roles of 5-HT2 receptor subtypes. Pharmacol. Biochem. Behav. 88: 367-373, 2008.
171. C. Watanabe, T. Orito, H. Watanabe, H. Mizoguchi, A. Yonezawa, K. Yanai, J.I. Mobarakeh, K. Onodera, T. Sakurada, S. Sakurada: Intrathecal high-dose histamine induces spinally-mediated behavioral responses through a polyamine site of NMDA receptors. Eur. J. Pharmacol. 581: 54-63, 2008.
172. S. Sakurada, T. Sawai, H. Mizoguchi, H. Watanabe, C. Watanabe, A. Yonezawa, M. Morimoto, T. Sato, T. Komatsu, T. Sakurada: Possible involvement of dynorphin A release via μ1-opioid receptor on supraspinal antinociception of endomorphin-2. Peptides 29: 1554-1560, 2008.
173. R. Russo, F. Cavaliere, C. Watanabe, C. Nucci, G. Bagetta, M.T. Corasaniti, S. Sakurada, L.A. Morrone: 17Beta-estradiol prevents retinal ganglion cell loss induced by acute rise of intraocular pressure in rat. Prog. Brain Res. 173: 583-590, 2008.
174. A. Yonezawa, M. Ebiko, M. Yoshizumi, S.N. Ise, C. Watanabe, H. Mizoguchi, M. Iwasaki, Y. Kimura, S. Sakurada: Effects of insulin replacement on ejaculatory dysfunction in streptozotocin-induced diabetic rats. Int. J. Urol. 16: 208-211, 2009.
175. A. Yonezawa, M. Yoshizumi, S.N. Ise, C. Watanabe, H. Mizoguchi, K. Furukawa, H. Tsuru, Y. Kimura, M. Kawatani, S. Sakurada: Synergistic actions of apomorphine and m-chlorophenylpiperazine on ejaculation, but not penile erection in rats. Biomed. Res. 30: 71-78, 2009.
176. T. Komatsu, M. Sasaki, K. Sanai, H. Kuwahata, C. Sakurada, M. Tsuzuki, Y. Iwata, S. Sakurada, T. Sakurada: Intrathecal substance P augments morphine-induced antinociception: possible relevance in the production of substance P N-terminal fragments. Peptides 30: 1689-1696, 2009.
177. T. Komatsu, S. Sakurada, K. Kohno, H. Shiohira, S. Katsuyama, C. Sakurada, M. Tsuzuki, T. Sakurada: Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide. Biochem. Pharmacol. 78: 1026-1034, 2009.
178. K. Tan-No, H. Takahashi, O. Nakagawasai, F. Niijima, S. Sakurada, G. Bakalkin, L. Terenius, T. Tadano: Nociceptive behavior induced by the endogenous opioid peptides dynorphins in uninjured mice: evidence with intrathecal N-ethylmaleimide inhibiting dynorphin degradation. Int. Rev. Neurobiol. 85: 191-205, 2009.
179. T. Komatsu, S. Sakurada, S. Katsuyama, K. Sanai, T. Sakurada: Mechanism of allodynia evoked by intrathecal morphine-3-glucuronide in mice. Int. Rev. Neurobiol. 85: 207-219, 2009.
180. L. Berliocchi, R. Russo, A. Levato, V. Fratto, G. Bagetta, S. Sakurada, T. Sakurada, N.B. Mercuri, M.T. Corasaniti: (-)-Linalool attenuates allodynia in neuropathic pain induced by spinal nerve ligation in c57/bl6 mice. Int. Rev. Neurobiol. 85: 221-235, 2009.
181. T. Sakurada, H. Kuwahata, S. Katsuyama, T. Komatsu, L.A. Morrone, M.T. Corasaniti, G. Bagetta, S. Sakurada: Intraplantar injection of bergamot essential oil into the mouse hindpaw: effects on capsaicin-induced nociceptive behaviors. Int. Rev. Neurobiol. 85: 237-248, 2009.
182. H. Mizoguchi, C. Watanabe, A. Yonezawa, S. Sakurada: New therapy for neuropathic pain. Int. Rev. Neurobiol. 85: 249-260, 2009.
183. L. Rombolà, M.T. Corasaniti, D. Rotiroti, C. Tassorelli, S. Sakurada, G. Bagetta, L.A. Morrone: Effects of systemic administration of the essential oil of bergamot (BEO) on gross behaviour and EEG power spectra recorded from the rat hippocampus and cerebral cortex. Funct. Neurol. 24: 107-112, 2009.
184. K. Okuyama, K. Wada, S. Sakurada, H. Mizoguchi, H. Komatsu, I. Sora, G. Tamura, Y. Ohkawara, M. Takayanagi, I. Ohno: The involvement of m-opioid receptors in the central nervous system in the worsening of allergic airway inflammation by psychological stress in mice. Int. Arch. Allergy Immunol. 152: 342-352, 2010.
185. G. Bagetta, L.A. Morrone, L. Rombolà, D. Amantea, R. Russo, L. Berliocchi, S. Sakurada, T. Sakurada, D. Rotiroti, M.T. Corasaniti: Neuropharmacology of the essential oil of bergamot. Fitoterapia (in press).
